Question 22N.1.HL.TZ0.29
| Date | November 2022 | Marks available | [Maximum mark: 1] | Reference code | 22N.1.HL.TZ0.29 |
| Level | HL | Paper | 1 | Time zone | TZ0 |
| Command term | Question number | 29 | Adapted from | N/A |
Antifreeze is a compound called ethylene glycol, which is metabolized in mammals to poisonous compounds that cause kidney failure, amongst other symptoms. The first step in metabolism involves an enzyme called alcohol dehydrogenase. Two inhibitors of this enzyme used in treating antifreeze poisoning are ethanol and fomepizole. The chemical structures of antifreeze and the two inhibitors are shown.
Studies have shown that fomepizole may be preferred to ethanol as a treatment. What is a reason for this?
A. Fomepizole is a competitive inhibitor and may be given in small doses.
B. Ethanol is a non-competitive inhibitor and may be given in small doses.
C. Fomepizole is a non-competitive inhibitor and must be given in very large doses.
D. Ethanol is a competitive inhibitor and must be given in very large doses.
[1]
D
