DP Chemistry (last assessment 2024)

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Question 20N.3.sl.TZ0.11d

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Date November 2020 Marks available [Maximum mark: 1] Reference code 20N.3.sl.TZ0.11d
Level sl Paper 3 Time zone TZ0
Command term Comment Question number d Adapted from N/A
d.
[Maximum mark: 1]
20N.3.sl.TZ0.11d

Aspirin is formed by reacting salicylic acid with ethanoic anhydride. The structure of aspirin is given in section 37 of the data booklet.

(d)

Comment on the risk of overdose when taking aspirin as an analgesic, referring to the following values, for a person weighing 70 kg:

Minimum therapeutic dose =0.5 g

Estimated minimum lethal dose =15 g

[1]

Markscheme

low/medium risk «of overdosing» AND «estimated» lethal dose is 30 times/much larger than therapeutic dose 

OR

30 times the dose results in chance of dying ✔

Accept “30 and low/medium risk due to large therapeutic index”.
Do not accept “low/medium risk AND large therapeutic window”.
Do not accept “30 times the dose” alone for the mark.

Examiners report

This is a topic that continues to challenge students and "low/medium risk AND large therapeutic window" was worryingly common. There were also many students who did not calculate the ratio correctly.

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