Meiosis 3.3

Meiosis is the process which allows sexual reproduction to be possible. It produces four haploid cells which make gametes. Sometimes non-disjunction can cause problems when the movement of chromosomes doesn't happen as it is supposed to. In this topic you cover how the chromosomes move during meiosis, crossing over of chromatids and non-disjunction leading to trisomy 21.

Key concepts

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Essentials

These slides summarise the essential understanding and skills in this topic. 
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Summary

Summary list for topic 3.3 Meiosis

  • Meiosis produces four haploid nuclei from one diploid nucleus.
  • Haploid nuclei allow a life cycle with fusion of gametes.
  • DNA is replicated before meiosis so that all chromosomes at start of meiosis are 'double stranded' with two sister chromatids.
  • The early stages of meiosis involve pairing of homologous chromosomes and crossing over followed by condensation.
  • Random orientation of pairs of homologous chromosomes.
  • Separation of pairs of homologous chromosomes in the first division of meiosis halves the chromosome number.
  • Genetic variation is the result of crossing over and random orientation.
  • Different parents providing gametes promotes genetic variation.

Mindmaps

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Exam style questions

Exam style question about genes

The skill of understanding the movement of chromosomes in meiosis is important in this topic.

Answer the question below on a piece of paper, then check your answer with the model answer.

The diagram shows the karyogram of a species of fly and the nuclei of four of its haploid spermatocyte cells after meiosis has taken place.

Explain how the nuclei of the cells in images E and G have become different sizes during the process of meiosis  [4]

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Extra exam question on meiosis and variation   - - - click the + to open it -- >

This question requires knowledge of the process of meiosis and how it produces variation in gametes.

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Question: Describe how meiosis promotes genetic variation in gametes (4 marks)

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Test yourself

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Drag and drop activities

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Trisomy 21 is the genetic cause of Down's syndrome.

Drag and drop the correct term or phrase into the gap to outline the cause of Down's syndrome and methods for embryonic karyotyping to test for the condition.

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age first two copies DNA mutation non-disjunction miscarriage chromosomal second risk fertilised three copies karyotype placenta sperm amniocentesis

Trisomy 21 is the mutation that causes Down’s syndrome. The cause is of chromosome pair 21 in the stage of meiosis leading to of chromosome 21 entering the ovum . On fertilisation, the contributes one more chromosome 21 leading to three being present in the ovum.

As the condition has been shown to be related to the of the mother, the embryo can be tested during pregnancy. This is done by analysis of cells taken from the embryonic part of the (chorionic villus sampling) or from the umbilical cord ( ). Both methods carry a degree of of damage to the foetus or of causing a .

The inheritance of an extra chromosome caused by non-disjuntion of a pair of chromatids in meiosis II is a chromosomal mutaion.


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