Question 19M.3.HL.TZ2.20b
| Date | May 2019 | Marks available | [Maximum mark: 2] | Reference code | 19M.3.HL.TZ2.20b |
| Level | HL | Paper | 3 | Time zone | TZ2 |
| Command term | Compare and contrast | Question number | b | Adapted from | N/A |
Most stomach ulcers are caused by a bacterium that lives under the mucus lining of the stomach wall.
This organism causes the production of reactive compounds which result in oxidation. This makes the ulcer progress and, consequently, healing is more difficult. A study was carried out to compare the effect of the drug nizatidine (N) alone or combined with the antioxidants vitamin E and thioctic acid.
[Source: Effect of Helicobacter Pylori Eradication Therapy and some Antioxidants on Ulcer Healing Rates
in Patients with Helicobacter pylori-associated Duodenal Ulcer, Ahmed M Ali, 2013, http://www.rroij.com/
open-access/effect-of-helicobacter-pylori-eradication-therapy-and-some-antioxidants-on-ulcer-healingrates-
in-patients-with-helicobacter-pylor-.php?aid=34774, licensed under a
Creative Commons Attribution 4.0 International License]
Compare and contrast the effect of adding antioxidants to nizatidine on the ulcer healing rate.
[2]
a. vitamin E and thioctic acid both improve healing rate «compared with nizatidine alone»
OR
all trials with antioxidant/three trials improve healing rate «compared to N alone» ✔
b. adding vitamin E increases healing rate more than adding thioctic acid
OR
adding both vitamin E and thioctic acid increases healing rate to highest level «but still less than 100 %» ✔
Giving values alone is not enough.
[Source: Effect of Helicobacter Pylori
Eradication Therapy and some Antioxidants
on Ulcer Healing Rates in Patients with
Helicobacter pylori-associated Duodenal
Ulcer, Ahmed M Ali, 2013, http://
www.rroij.com/open-access/effect-ofhelicobacter-
pylori-eradication-therapy-andsome-
antioxidants-on-ulcer-healing-rates-inpatients-
with-helicobacter-pylor-.php?
aid=34774, licensed under a Creative
Commons Attribution 4.0 International
License]
The majority could contrast the effect, but it was more difficult for some also to provide a comparison, that is, similarities; many had some difficulty organizing their answer, although correct.
