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DP IB Biology: SL

Revision Notes

Home / IB / Biology: SL / DP / Revision Notes / 3. Genetics / 3.1 Genes & Chromosomes / 3.1.2 Alleles


3.1.2 Alleles


Alleles

  • A gene codes for a specific polypeptide that can affect a specific trait or characteristic in an organism
    • Eg. blood type

  • Alternative forms of a gene can exist, these various specific forms are called alleles
    • Note that although alleles are different forms of the same gene, they all still occupy the same locus on the chromosome
    • New alleles occur through mutations

  • Multiple alleles can exist for a gene that determines a specific trait
    • Each allele results in a different variation of that trait
      • Eg. blood types A, B, AB and O
  • The chromosomes of eukaryotic cells occur in homologous pairs (there are two copies of each chromosome, one copy inherited from each parent) which means that cells have two copies of every gene
    • As a result, a cell possesses two alleles of every gene within its nucleus
    • When the two alleles at a locus are the same/identical they are described as homozygous
    • When the two alleles at a locus are different they are described as heterozygous
  • Chromosomes showing gene and loci, downloadable AS & A Level Biology revision notes

    Chromosomes showing genes, loci and alleles

    Differences between Alleles

    • Alleles differ from each other by one or only a few bases
    • Even a very small change in base sequence can bring about a large effect in gene function, with a large knock-on effect on the phenotype
    • Even though different alleles of a gene have slightly different base sequences, they still occupy the same locus on the chromosome
    • Since the Human Genome Project, sophisticated techniques can analyse different alleles
    • These techniques are becoming faster, more accurate and more accessible to individuals
      • Comparable sequences can be analysed down to individual bases to determine evolutionary relationships
      • The more differences in base sequence, the further apart two species are in evolutionary terms
    • The exact positions where bases differ between alleles are called SNPs or snips (Single Nucleotide Polymorphisms)
      • An allele can have several snips but still only differ by a few bases from its other allele

    Exam Tip

    Use the term allele wherever possible in written answers, as it's always a more precise term than gene.



    • 1. Cell Biology
      • 1.1 Cells: Theory
        • 1.1.1 Cell Theory
          • 1.1.2 Functions of Life
            • 1.1.3 Surface Area to Volume Ratio
              • 1.1.4 Cell Specialisation
                • 1.1.5 Stem Cells
                  • 1.1.6 Skills: Cell Theory
                  • 1.2 Cells: Origin & Ultrastructure
                    • 1.2.1 Origin of Cells
                      • 1.2.2 Endosymbiotic Theory
                        • 1.2.3 Prokaryotic Cell Structure
                          • 1.2.4 Eukaryotic Cell Structure
                            • 1.2.5 Exocrine Pancreatic & Palisade Mesophyll Cells
                              • 1.2.6 Comparison of Prokaryotic & Eukaryotic Cells
                                • 1.2.7 Microscopes
                                  • 1.2.8 Skills: Drawing Cells
                                    • 1.2.9 Skills: Cell Origin & Ultrastructure
                                    • 1.3 Cells: Membrane Structure & Transport
                                      • 1.3.1 Phospholipid Bilayer Properties
                                        • 1.3.2 Membrane Proteins
                                          • 1.3.3 History of Fluid Mosaic Model
                                            • 1.3.4 Membrane Transport
                                              • 1.3.5 Active Transport & Bulk Transport
                                                • 1.3.6 Skills: Membrane Structure & Transport
                                                  • 1.3.7 Skills: Estimation of Osmolarity
                                                  • 1.4 Cells: Division
                                                    • 1.4.1 Cell Cycle
                                                      • 1.4.2 Phases of Mitosis
                                                        • 1.4.3 Cancer
                                                          • 1.4.4 Skills: Cell Division
                                                        • 2. Molecular Biology
                                                          • 2.1 Metabolism & Water
                                                            • 2.1.1 Molecules
                                                              • 2.1.2 Metabolism
                                                                • 2.1.3 Hydrogen Bonds
                                                                  • 2.1.4 Water
                                                                  • 2.2 Carbohydrates & Lipids
                                                                    • 2.2.1 Carbohydrates
                                                                      • 2.2.2 Fatty Acids
                                                                        • 2.2.3 Lipids
                                                                          • 2.2.4 Skills: Visualising Carbohydrates
                                                                            • 2.2.5 Skills: Calculating BMI
                                                                            • 2.3 Proteins
                                                                              • 2.3.1 Proteins
                                                                                • 2.3.2 Protein Structure & Function
                                                                                  • 2.3.3 The Variety of Proteins
                                                                                    • 2.3.4 Skills: Molecules
                                                                                    • 2.4 Enzymes
                                                                                      • 2.4.1 Enzymes
                                                                                        • 2.4.2 Immobilised Enzymes
                                                                                          • 2.4.3 Skills: Enzyme Experiments
                                                                                          • 2.5 Nucleic Acids: Structure & DNA Replication
                                                                                            • 2.5.1 DNA & RNA Structure
                                                                                              • 2.5.2 DNA Replication
                                                                                                • 2.5.3 Skills: DNA Replication
                                                                                                • 2.6 Transcription & Translation
                                                                                                  • 2.6.1 Transcription
                                                                                                    • 2.6.2 Translation
                                                                                                      • 2.6.3 Biotechnology
                                                                                                        • 2.6.4 Skills: DNA, RNA & Protein Synthesis
                                                                                                          • 2.6.5 Skills: Interpreting Sequences
                                                                                                          • 2.7 Cellular Respiration
                                                                                                            • 2.7.1 Cellular Respiration
                                                                                                              • 2.7.2 Anaerobic Respiration
                                                                                                                • 2.7.3 Aerobic Respiration
                                                                                                                  • 2.7.4 Skills: Respiration
                                                                                                                  • 2.8 Photosynthesis
                                                                                                                    • 2.8.1 Photosynthesis
                                                                                                                      • 2.8.2 Photosynthesis Continued
                                                                                                                        • 2.8.3 Skills: Photosynthesis
                                                                                                                          • 2.8.4 Skills: Separating Photosynthetic Pigments
                                                                                                                        • 3. Genetics
                                                                                                                          • 3.1 Genes & Chromosomes
                                                                                                                            • 3.1.1 Genes
                                                                                                                              • 3.1.2 Alleles
                                                                                                                                • 3.1.3 Mutation
                                                                                                                                  • 3.1.4 Genome
                                                                                                                                    • 3.1.5 Prokaryotic Chromosomes
                                                                                                                                      • 3.1.6 Eukaryotic Chromosomes
                                                                                                                                        • 3.1.7 Chromosome Number
                                                                                                                                          • 3.1.8 Sex Determination
                                                                                                                                            • 3.1.9 Karyograms
                                                                                                                                              • 3.1.10 Skills: Using Databases
                                                                                                                                              • 3.2 Meiosis
                                                                                                                                                • 3.2.1 Meiosis
                                                                                                                                                  • 3.2.2 Stages of Meiosis
                                                                                                                                                    • 3.2.3 Genetic Variation
                                                                                                                                                      • 3.2.4 Non-disjunction
                                                                                                                                                        • 3.2.5 Skills: Meiosis
                                                                                                                                                        • 3.3 Inheritance
                                                                                                                                                          • 3.3.1 Inheritance
                                                                                                                                                            • 3.3.2 Inheriting Alleles
                                                                                                                                                              • 3.3.3 Skills: Inheritance
                                                                                                                                                                • 3.3.4 Inheritance of Genetic Diseases
                                                                                                                                                                  • 3.3.5 Mutations & Disease
                                                                                                                                                                  • 3.4 Genetic Modification & Biotechnology
                                                                                                                                                                    • 3.4.1 Electrophoresis & PCR
                                                                                                                                                                      • 3.4.2 DNA Profiling
                                                                                                                                                                        • 3.4.3 Genetic Modification
                                                                                                                                                                          • 3.4.4 Cloning
                                                                                                                                                                            • 3.4.5 Skills: Genetic Modification & Biotechnology
                                                                                                                                                                          • 4. Ecology
                                                                                                                                                                            • 4.1 Species, Communities, Ecosystems & Energy Flow
                                                                                                                                                                              • 4.1.1 Species & Population
                                                                                                                                                                                • 4.1.2 Methods of Nutrition
                                                                                                                                                                                  • 4.1.3 Community
                                                                                                                                                                                    • 4.1.4 Nutrient Cycling
                                                                                                                                                                                      • 4.1.5 Energy Flow
                                                                                                                                                                                        • 4.1.6 Energy Losses
                                                                                                                                                                                          • 4.1.7 Skills: Species, Communities, Ecosystems & Energy Flow
                                                                                                                                                                                            • 4.1.8 Skills: Chi-squared test & Statistical Significance
                                                                                                                                                                                              • 4.1.9 Skills: Pyramids of Energy
                                                                                                                                                                                              • 4.2 Carbon Cycling & Climate Change
                                                                                                                                                                                                • 4.2.1 Carbon Cycle: Carbon Dioxide
                                                                                                                                                                                                  • 4.2.2 Carbon Cycle: Carbon Dioxide in the Atmosphere
                                                                                                                                                                                                    • 4.2.3 Carbon Cycle: Methane
                                                                                                                                                                                                      • 4.2.4 Carbon Cycle: Organic Matter
                                                                                                                                                                                                        • 4.2.5 Climate Change: Greenhouse Effect
                                                                                                                                                                                                          • 4.2.6 Climate Change: Impact
                                                                                                                                                                                                            • 4.2.7 Climate Change: Causes
                                                                                                                                                                                                              • 4.2.8 Skills: Carbon Cycling & Climate Change
                                                                                                                                                                                                            • 5. Evolution and biodiversity
                                                                                                                                                                                                              • 5.1 Evolution & Natural Selection
                                                                                                                                                                                                                • 5.1.1 Evolution
                                                                                                                                                                                                                  • 5.1.2 Evolution: Evidence
                                                                                                                                                                                                                    • 5.1.3 Variation
                                                                                                                                                                                                                      • 5.1.4 Natural Selection
                                                                                                                                                                                                                        • 5.1.5 Natural Selection Examples
                                                                                                                                                                                                                        • 5.2 Classification & Cladistics
                                                                                                                                                                                                                          • 5.2.1 Classification System
                                                                                                                                                                                                                            • 5.2.2 Classifying Organisms
                                                                                                                                                                                                                              • 5.2.3 Plant Phyla Features
                                                                                                                                                                                                                                • 5.2.4 Animal Phyla Features
                                                                                                                                                                                                                                  • 5.2.5 Cladistics
                                                                                                                                                                                                                                    • 5.2.6 Reclassification
                                                                                                                                                                                                                                      • 5.2.7 Skills: Classification & Cladistics
                                                                                                                                                                                                                                    • 6. Human Physiology
                                                                                                                                                                                                                                      • 6.1 Digestion & Absorption
                                                                                                                                                                                                                                        • 6.1.1 Digestion
                                                                                                                                                                                                                                          • 6.1.2 Villi & Absorption
                                                                                                                                                                                                                                            • 6.1.3 Absorption
                                                                                                                                                                                                                                              • 6.1.4 Skills: Digestion & Absorption
                                                                                                                                                                                                                                              • 6.2 The Blood System
                                                                                                                                                                                                                                                • 6.2.1 The Blood System: History
                                                                                                                                                                                                                                                  • 6.2.2 The Blood System: Vessels
                                                                                                                                                                                                                                                    • 6.2.3 The Blood System: Double Circulation
                                                                                                                                                                                                                                                      • 6.2.4 The Blood System: Cardiac Cycle
                                                                                                                                                                                                                                                        • 6.2.5 The Heart Rate
                                                                                                                                                                                                                                                          • 6.2.6 Skills: The Blood System
                                                                                                                                                                                                                                                          • 6.3 Defence Against Infectious Disease
                                                                                                                                                                                                                                                            • 6.3.1 Skin
                                                                                                                                                                                                                                                              • 6.3.2 Blood Clotting
                                                                                                                                                                                                                                                                • 6.3.3 White Blood Cells
                                                                                                                                                                                                                                                                  • 6.3.4 Antibiotics
                                                                                                                                                                                                                                                                    • 6.3.5 Antibiotic Resistance
                                                                                                                                                                                                                                                                    • 6.4 Gas Exchange
                                                                                                                                                                                                                                                                      • 6.4.1 Ventilation: Function & Structures
                                                                                                                                                                                                                                                                        • 6.4.2 Ventilation: Mechanism
                                                                                                                                                                                                                                                                          • 6.4.3 Lung Diseases
                                                                                                                                                                                                                                                                            • 6.4.4 Skills: Monitoring Ventilation
                                                                                                                                                                                                                                                                            • 6.5 Neurones & Synapses
                                                                                                                                                                                                                                                                              • 6.5.1 Neurones: Function & Structure
                                                                                                                                                                                                                                                                                • 6.5.2 Nerve Impulses
                                                                                                                                                                                                                                                                                  • 6.5.3 Synapses
                                                                                                                                                                                                                                                                                    • 6.5.4 Skill: Neurones & Synapses
                                                                                                                                                                                                                                                                                    • 6.6 Hormones, Homeostasis & Reproduction
                                                                                                                                                                                                                                                                                      • 6.6.1 Hormones
                                                                                                                                                                                                                                                                                        • 6.6.2 Hormones Continued
                                                                                                                                                                                                                                                                                          • 6.6.3 Reproduction: Background
                                                                                                                                                                                                                                                                                            • 6.6.4 Reproduction: Sex Determination in Males
                                                                                                                                                                                                                                                                                              • 6.6.5 Reproduction: Sex Determination in Females
                                                                                                                                                                                                                                                                                                • 6.6.6 Skills: Reproduction Diagrams
                                                                                                                                                                                                                                                                                              Phil Chatterton

                                                                                                                                                                                                                                                                                              Author: Phil

                                                                                                                                                                                                                                                                                              Phil graduated in Biochemistry from Birmingham University and spent seventeen years in the drinks and chemicals industries. He holds an MBA from Manchester Business School. More recently, Phil has taught in secondary schools, examined GCSE Biology and has also co-directed a tuition agency. He is a passionate believer in promoting numeracy in his teaching and loves to create innovative resources.


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